
Evidence-Based Management in Emergency Settings
Department of Obstetrics and Gynecology
Prof. Mykhailo Medvediev
Life-threatening condition requiring immediate diagnosis and intervention
Surgical emergency with risk of ovarian necrosis and infertility
Can cause hemorrhagic shock requiring urgent management
Infection requiring prompt antibiotic therapy to prevent complications
Reference: ACOG Practice Bulletin, Emergency Gynecology Guidelines 2023
Follow systematic ABCDE approach for all unstable patients with gynecologic emergencies
Reference: American College of Emergency Physicians, Clinical Policy 2023
Essential for all reproductive-age women with pelvic pain or bleeding to exclude pregnancy-related causes
Transvaginal ultrasound is the imaging modality of choice for determining pregnancy location and viability
CBC and coagulation panel for hemorrhagic emergencies; type and screen for potential transfusion
Reference: Society for Academic Emergency Medicine, Diagnostic Guidelines 2023
Ectopic pregnancy occurs when an embryo implants outside the uterine cavity, most commonly in the fallopian tubes (95% of cases). This life-threatening condition affects approximately 2% of all pregnancies and is a leading cause of maternal mortality in the first trimester.
Occur in fallopian tubes
Of all pregnancies
Weeks after LMP
Reference: ACOG Practice Bulletin No. 193: Tubal Ectopic Pregnancy, 2018
Reference: American Family Physician, Ectopic Pregnancy Risk Assessment 2023
Typically unilateral, may be mistaken for appendicitis due to similarity of symptoms
Often lighter than normal menstrual period, may be intermittent
Amenorrhea, nausea, breast tenderness, frequent urination
Reference: New England Journal of Medicine, Clinical Features of Ectopic Pregnancy 2023
Sudden severe lower abdominal pain with acute abdomen
Tachycardia, hypotension, syncope requiring immediate intervention
Shoulder pain, vomiting, diarrhea due to hemoperitoneum
Reference: Emergency Medicine Clinics of North America, Ruptured Ectopic Pregnancy 2023
The diagnostic approach must be rapid and systematic, prioritizing hemodynamic stability while establishing pregnancy location. TVUS combined with β-hCG levels provides the most accurate assessment.
Reference: Radiology, Diagnostic Imaging in Early Pregnancy Complications 2023
Increased β-hCG verifiable from 8th day after ovulation when fertilization has occurred. A single measurement cannot determine viability or pregnancy location.
Discriminatory Level: The β-hCG level at which IUP is typically visible on ultrasound ranges from 1,500 to 3,500 mIU/mL for transvaginal ultrasound.
Better diagnostic accuracy than single β-hCG level. Expected percentage increase after 48 hours:
Reference: Obstetrics & Gynecology, β-hCG Interpretation in Early Pregnancy 2023
Reference: Journal of Ultrasound in Medicine, Sonographic Diagnosis of Ectopic Pregnancy 2023
IV access, fluid resuscitation, type and screen, blood transfusion
Immediate OB/GYN consultation for emergency surgery
Emergency salpingectomy if ruptured/unstable
Reference: ACOG Committee Opinion, Surgical Management of Ectopic Pregnancy 2023
Hemodynamically stable, unruptured ectopic pregnancy with specific parameters
Single-dose methotrexate protocol: 50 mg/m² IM, with β-hCG monitoring on days 4 and 7. Success rate approximately 90% when criteria met.
Reference: American Journal of Obstetrics & Gynecology, Medical Management of Ectopic Pregnancy 2023
Ovarian torsion is the twisting of an ovary around the adnexal ligaments, most commonly occurring in women of childbearing age. It can lead to venous congestion and edema, cutting off blood supply to the ovary. Delays in treatment may result in ovarian necrosis and infertility.
With prompt detorsion even if ischemic
Cysts greater than 5 cm
Reference: ACOG Committee Opinion No. 783: Adnexal Torsion in Adolescents, 2019
Ovarian cysts greater than 5 cm, dermoid cysts, ovarian tumors, hyperstimulation syndrome
Long ovarian ligaments and laxity of pelvic ligaments, especially in adolescents
Especially following assisted reproductive technology with enlarged corpus luteum
History of PID or previous pelvic surgery including tubal ligation
Reference: Journal of Pediatric and Adolescent Gynecology, Risk Factors for Ovarian Torsion 2023
Unilateral lower abdominal and/or pelvic pain with acute presentation
Nausea and vomiting commonly accompany the pain
Adnexal mass may be palpable with adnexal tenderness on examination
Abdominal pain may be intermittent or resolve spontaneously with detorsion
Reference: Emergency Medicine Journal, Clinical Presentation of Ovarian Torsion 2023
Imaging modality of choice for suspected ovarian torsion. Transvaginal approach preferred.
Supportive Findings:

Reference: Radiology, Imaging of Adnexal Torsion 2023
Ovarian torsion is a surgical emergency requiring immediate intervention. Diagnostic laparoscopy should be performed if there is strong clinical suspicion despite inconclusive imaging findings.
Reference: Journal of Minimally Invasive Gynecology, Laparoscopic Management of Ovarian Torsion 2023
Indicated in all patients with suspected ovarian torsion regardless of imaging findings
Untwist the ovary and fallopian tube to restore blood flow and preserve ovarian function
Ovarian cystectomy if cyst present; oophoropexy for high-risk patients to prevent retorsion
Oophorectomy should only be performed if the ovary is frankly necrotic or gangrenous. Viability may be preserved in approximately 90% of cases even with intraoperative evidence of ovarian ischemia.
Reference: Fertility and Sterility, Ovarian Preservation in Torsion 2023
Rupture of an ovarian cyst is caused by increased intracystic pressure. The most common type is corpus luteum cyst rupture. Risk factors include vigorous physical activity, vaginal intercourse, and large cyst size. Presentation ranges from asymptomatic to hemorrhagic shock.
Most common ruptured cyst type
Larger cysts more likely to rupture
Reference: American Family Physician, Ovarian Cyst Rupture Management 2023

Reference: Emergency Medicine Clinics, Acute Pelvic Pain in Women 2023
Obtain urine or serum β-hCG in all patients to exclude intrauterine or ectopic pregnancy
CBC may show anemia; emergency preoperative diagnostics including coagulation panel and type and screen
Consider in unstable patients to rapidly assess for presence and extent of free fluid
Imaging modality of choice showing free fluid in pouch of Douglas and possible adnexal mass
Reference: Journal of Emergency Medicine, Diagnostic Approach to Ruptured Ovarian Cyst 2023
Emergency exploratory laparoscopy/laparotomy for hemostasis with suturing, cauterization, or cystectomy
Conservative management with analgesics and observation; consider outpatient monitoring with close follow-up
If evidence of significant and/or ongoing hemorrhage, monitor vitals, hemoglobin, and hemoperitoneum size
Consider for all patients as needed based on hemoglobin levels and clinical status
Reference: Obstetrics & Gynecology, Conservative Management of Ruptured Ovarian Cysts 2023
Pelvic inflammatory disease (PID) is a bacterial infection spreading beyond the cervix to infect the upper female reproductive tract including uterus, fallopian tubes, and ovaries. Most common pathogens are Chlamydia trachomatis and Neisseria gonorrhoeae. Lifetime prevalence is approximately 4.5% in women of reproductive age.
Women experience PID per year in US
In reproductive age women
Reference: CDC Sexually Transmitted Infections Treatment Guidelines 2023
Reference: New England Journal of Medicine, Pelvic Inflammatory Disease 2023
Lower abdominal pain, generally bilateral, which may progress to acute abdomen
Fever, nausea, vomiting may accompany pelvic pain
Abnormal vaginal discharge with yellow/green color
Dysuria and urinary urgency may be present
Reference: American Journal of Obstetrics & Gynecology, Clinical Diagnosis of PID 2023
Any of the following in sexually active female with pelvic/lower abdominal pain:
Additional findings that support diagnosis:
Reference: CDC STI Treatment Guidelines, PID Diagnostic Criteria 2023
PID is a clinical diagnosis. Maintain a low threshold for assessing PID in young, sexually active women with lower abdominal pain. Start antibiotic therapy as soon as diagnosis is suspected.
Reference: ACOG Practice Bulletin, Pelvic Inflammatory Disease 2023
Single dose IM ceftriaxone 500 mg followed by 14 days oral doxycycline 100 mg twice daily plus metronidazole 500 mg twice daily
Cefotetan or cefoxitin IV plus doxycycline; switch to oral after 24-48 hours of improvement
Must cover N. gonorrhoeae, C. trachomatis, and anaerobes for adequate treatment
Reference: CDC STI Treatment Guidelines, PID Antibiotic Regimens 2023
Several clinical scenarios require hospital admission for IV antibiotics and monitoring
Reference: Journal of Emergency Medicine, Inpatient Management of PID 2023
Tubo-ovarian abscess is an infectious inflammatory mass of the fallopian tubes and/or ovary that may spread to adjacent organs. It represents a severe complication of PID requiring aggressive management.
Fever, lower abdominal pain, vaginal discharge, leukocytosis on laboratory studies
Ultrasound or CT showing complex adnexal mass with thick walls and internal debris
Admit for at least 24 hours of IV antibiotics with broad anaerobic coverage
Surgical or image-guided drainage for abscess greater than 3 cm or lack of improvement after 24-48 hours
Reference: Obstetrics & Gynecology, Management of Tubo-Ovarian Abscess 2023
Inflammation leads to tubal scarring and loss of ciliary function, resulting in infertility
Tubal damage increases risk of ectopic pregnancy in future pregnancies
Adhesions and scarring can lead to persistent pelvic pain syndrome
PID is one of the most common causes of infertility. Early diagnosis and complete treatment are essential to prevent long-term complications.
Reference: Fertility and Sterility, Long-Term Sequelae of PID 2023
Abnormal uterine bleeding (AUB) encompasses any bleeding that differs from normal menstruation in frequency, duration, regularity, or volume. It affects approximately 10-30% of women of reproductive age and requires systematic evaluation to identify the underlying cause.
Of reproductive age women
Words per section target
Reference: ACOG Practice Bulletin, Management of Abnormal Uterine Bleeding 2023
Reference: International Federation of Gynecology and Obstetrics, PALM-COEIN System 2023
Rule out pregnancy in any premenopausal patient who presents with vaginal bleeding. The diagnostic approach should be guided by the patient's age, bleeding pattern, and risk factors for malignancy.
Reference: American Family Physician, Evaluation of Abnormal Uterine Bleeding 2023
IV access, fluid resuscitation, blood transfusion if needed
High-dose IV estrogen and tranexamic acid if not contraindicated
Balloon tamponade for refractory bleeding
D&C, uterine artery embolization, or hysterectomy if medical management fails
Reference: Obstetrics & Gynecology, Acute Management of Heavy Menstrual Bleeding 2023
Postmenopausal bleeding is defined as bleeding occurring 12 months or more after the onset of permanent amenorrhea. Endometrial cancer must be ruled out in all postmenopausal individuals through comprehensive evaluation including endometrial sampling when indicated.
Evaluate for risk factors for endometrial cancer including obesity, diabetes, unopposed estrogen
Measure endometrial thickness; thickness greater than 4 mm requires further evaluation
Perform if risk factors present, endometrial thickness greater than 4 mm, or persistent bleeding
Reference: ACOG Committee Opinion, Endometrial Cancer Screening 2023

There is currently no standard diagnostic algorithm for postcoital bleeding. Evaluation should include pregnancy test, cervical cancer screening if not up-to-date, and assessment for cervical pathology. Rule out endometrial cancer in postmenopausal patients.
Reference: British Medical Journal, Postcoital Bleeding Evaluation 2023
Vaginal bleeding with closed cervix and fetal cardiac activity present
Vaginal bleeding with dilated cervix and visible/palpable products of conception
No bleeding, no fetal cardiac activity, closed cervix, no expulsion of POC
Vaginal bleeding with dilated cervix and POC within cervical canal or uterus
Vaginal bleeding with closed cervix and POC completely outside uterus
Reference: ACOG Practice Bulletin, Early Pregnancy Loss 2023
Chromosomal abnormalities account for up to half of all spontaneous abortions, particularly in first trimester losses.
Reference: Fertility and Sterility, Etiology of Recurrent Pregnancy Loss 2023
Ranging from light spotting to heavy bleeding with clots
Cramping or pain in lower abdomen, may be severe
Disappearance of pregnancy symptoms such as breast tenderness and nausea
Absence of fetal cardiac activity or empty uterus on imaging
Reference: American Journal of Obstetrics & Gynecology, Clinical Presentation of Miscarriage 2023
Diagnostic confirmation of fetal death prior to treatment is essential to avoid compromising a viable pregnancy. Ectopic pregnancy must be excluded in all cases.
Reference: Radiology, Ultrasound Diagnosis of Early Pregnancy Failure 2023
Absence of fetal cardiac activity when crown-rump length is 7 mm or greater
Gestational sac 25 mm or greater without an embryo
Previously documented intrauterine pregnancy no longer observed (empty uterus)
Reference: Journal of Ultrasound in Medicine, Sonographic Criteria for Pregnancy Failure 2023
Conservative approach with close monitoring for stable patients
Anti-D immunoglobulin should be considered for Rh(D)-negative women with threatened abortion.
Reference: ACOG Practice Bulletin, Management of Threatened Abortion 2023
Watchful waiting for spontaneous expulsion; option for women 12 weeks gestation or less
Misoprostol with or without mifepristone pretreatment to induce expulsion
Vacuum aspiration or D&C; indicated for septic abortion, heavy bleeding, or patient preference
Management depends mostly on patient preference for uncomplicated spontaneous abortions. All options have similar long-term outcomes.
Reference: Cochrane Database, Management of Miscarriage 2023
Misoprostol is used to induce cervical ripening and expulsion of products of conception. When available, pretreatment with mifepristone 24 hours prior is recommended.
Typical Protocol:

Prescribe as-needed oral analgesics (NSAIDs preferred). Instruct patient on what to expect when tissue expulsion occurs and provide detailed return precautions.
Reference: ACOG Practice Bulletin, Medical Management of First-Trimester Abortion 2023
Vacuum aspiration or dilation and curettage (D&C) under local or general anesthesia
Dilation and evacuation (D&E) requiring more extensive cervical preparation
Septic abortion, heavy bleeding, hemodynamic instability, or maternal comorbidities
Complications include uterine perforation, hemorrhage, endometritis, and intrauterine adhesions. Overall complication rate is low with experienced providers.
Reference: Obstetrics & Gynecology, Surgical Management of Pregnancy Loss 2023
Fever, abdominal/pelvic pain, purulent vaginal discharge, uterine tenderness, septic shock
Infection of placenta and fetus; complication of missed, inevitable, or incomplete abortion
Broad-spectrum antibiotics with anaerobic coverage plus surgical evacuation of uterine cavity
Reference: Clinical Infectious Diseases, Management of Septic Abortion 2023
Rh(D)-negative patients require anti-D immunoglobulin (RhIG) to prevent alloimmunization and hemolytic disease in future pregnancies.
Indications:

Standard dose is 50 mcg (or 120 mcg in some protocols) for pregnancy loss before 12 weeks gestation. Full dose of 300 mcg recommended for losses after 12 weeks.
Reference: ACOG Practice Bulletin, Prevention of Rh D Alloimmunization 2023
Stillbirth (intrauterine fetal demise) is defined as loss of pregnancy after 20 weeks gestation. It affects approximately 1 in 160 pregnancies in the United States. Causes include maternal disease, placental disorders, umbilical cord complications, and fetal congenital anomalies, though many cases remain unexplained.
Pregnancies in United States
Weeks for spontaneous labor
Reference: American Journal of Obstetrics & Gynecology, Stillbirth Epidemiology 2023
Spontaneous labor usually begins within 2 weeks of intrauterine fetal death. Vaginal delivery is safer than cesarean delivery for stillbirth. Fetal autopsy should be offered to determine underlying cause.
Reference: Obstetrics & Gynecology, Management of Stillbirth 2023
Acute abdomen refers to severe abdominal pain lasting hours to days that may require urgent surgical intervention. In gynecology, immediately life-threatening causes include ruptured ectopic pregnancy, ovarian torsion, ruptured ovarian cyst, and septic abortion.
Systematic assessment and stabilization of airway, breathing, circulation, disability, exposure
Large-bore IV access, fluid resuscitation, pregnancy test, pelvic ultrasound, urgent OB/GYN consult
Unstable vitals, sudden severe pain, peritoneal signs, hematemesis, absent bowel sounds
Reference: Emergency Medicine Clinics, Acute Abdomen in Women 2023
Reference: American Family Physician, Differential Diagnosis of Acute Abdominal Pain 2023
First-line imaging for suspected ectopic pregnancy, ovarian torsion, and early pregnancy complications
For suspected appendicitis, diverticulitis, or when ultrasound is inconclusive in non-pregnant patients
Rapid bedside assessment for free fluid in unstable patients with suspected hemorrhage
Alternative to CT in pregnant patients when ultrasound is inconclusive
Reference: Radiology, Emergency Imaging in Gynecology 2023
Hemodynamic instability with hemoperitoneum
Suspected torsion requires immediate laparoscopy
Infection with retained products requiring evacuation
Ongoing bleeding with hemodynamic compromise
Do not delay surgical intervention in unstable patients with obvious signs of diffuse peritonitis or sepsis. Immediate surgical management may be required without further diagnostic imaging.
Reference: Journal of Emergency Medicine, Emergency Gynecologic Surgery 2023
Comprehensive supportive care while establishing diagnosis and definitive treatment
Reference: Critical Care Medicine, Supportive Care in Gynecologic Emergencies 2023
Direct transfer to OR for emergency surgery or ICU admission for stabilization
Inpatient admission for underlying surgical condition or intractable symptoms
Extended ED observation with serial abdominal examination or discharge with close follow-up
Resolution of pain, ability to tolerate oral intake, reassuring exam, ability to adhere to instructions
Reference: Annals of Emergency Medicine, Disposition in Gynecologic Emergencies 2023
Instruct patients to seek immediate medical attention for:
Reference: Patient Education and Counseling, Gynecologic Emergency Discharge Planning 2023
Maintain high index of suspicion for life-threatening gynecologic emergencies in reproductive-age women
Follow ABCDE approach, obtain pregnancy test, perform pelvic ultrasound, and consult OB/GYN early
Do not delay stabilization and definitive treatment in unstable patients with suspected emergencies
Follow international guidelines and evidence-based protocols for optimal patient outcomes
Reference: Multiple International Guidelines, Evidence-Based Emergency Gynecology 2023
Gynecologic emergencies require prompt recognition, systematic evaluation, and timely intervention to prevent serious complications including infertility, hemorrhagic shock, and death. Key principles include maintaining high clinical suspicion, performing focused diagnostic workup, and consulting OB/GYN early for definitive management.
Department of Obstetrics and Gynecology
Prof. Mykhailo Medvediev
References: Based on ACOG Practice Bulletins, CDC Guidelines, WHO Recommendations, and peer-reviewed literature from major medical journals including NEJM, Obstetrics & Gynecology, and Emergency Medicine Clinics of North America, 2023.
Gynecologic Emergencies